PIPER BETEL-HEPATOPROTECTIVE
An in vivo study was conducted to evaluate the hepatoprotective activity of ethanolic extracts of Piper betel leaves. Liver damage was induced in male Wister rats weighed 150-200 gm by administering CCl4 (2ml/kg i.p) regularly for 10days and tissue damage was noted by various biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT),
serum glutamate Pyruvate transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lipidperoxidation, Level of antioxidant enzy -me like catalase (CAT), Superoxide dismutase (SOD), Glutathione (GSH) in liver. Ethanolic extract of piper betel 100 mg/kg and 200 mg/kg i.p administered regularly for 10 days and compared with acontrol group silymarin (25 mg/kg i.p.).
A significant reduction in serum SGOT, SGPT, ALP, ACP, lipid peroxidation andimprovement in CAT, SOD, GSH, MDA level in the liver were observed when compared with CCl4 administered rats.
Piper betel leaves extract (PBLE) was able to protect the liver against the oxidative damage produced by CCl4.
The thick, red, scaly skin of psoriasis can be not only painful but also embarrassing. Most people get psoriasis on their elbows, knees, scalp, back, face, palms and feet. It can show up on other parts of the body, too, including fingernails, toenails, genitals and inside the mouth. Besides being uncomfortable, these patches of skin can make you self-conscious about the way you look. Psoriasis can be socially isolating for many people," "Often, people can become depressed."Psoriasis is not a disease you can catch from others. It's caused by an overactive immune system. The immune system essentially raises false alarms, which lead to inflammation and a rapid turnover of skin cells. Normally, skin cells take about a month to grow deep in your skin and then rise to the surface. In psoriasis, the cells rise in a matter of days, before they have a chance to mature. The new cells and existing cells all pile up on the surface of the skin. The result is redness, irritation and discomfort.
unfortunately, psoriasis can affect more than just the skin. It causes some people to have swollen joints and arthritis. Studies have also linked psoriasis to higher risks for diabetes, obesity, abnormal cholesterol, strokes and heart attacks.
For these reasons, it's especially important for psoriasis patients to get their blood pressure checked, quit smoking if they smoke and maintain a healthy body weight," Gelfand says. Researchers are continuing to look into the causes of psoriasis. The genes you inherit affect your chances of getting the disease, but other factors are also involved, too. "We're understanding more about psoriasis every day that the past decade has brought about more treatments for psoriasis than ever before. Doctors now have many more options to help their patients manage and cope with the disorder.
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